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. 2019 Feb 14;13(2):e0007083. doi: 10.1371/journal.pntd.0007083

Table 1. Mouse strains/models used for MAC infection.

Mouse strain M. avium route of infection and dose Productive infection (organ) Compound screening Reference
C57BL/6 aerosolization; approximately 105/mouse lung and spleen CLR [100]
C57BL/6 (modified Cornell-like model) M. avium complex strains; aerosolization (500–104 CFU/ mouse) lung CLR-RIF [103]
C57BL/6 M. avium subsp. hominissuis; intranasal 2.25 × 107 CFU/mouse lung LAI [150]
C57BL/10 intranasal; 105 CFU/mouse lung, spleen, and liver N/A [101]
129Sv IV; 106 CFU/mouse lung, spleen, and liver N/A [96]
BALB/c aerosolization; approximately 105 CFU/mouse lung and spleen CLR, CLR-EMB-RIF, MXF-EMB-RIF, CLR-MXF-EMB-RIF [100]
iNOS-/- IV; 106 CFU/mouse liver N/A [151]
iNOS-/- IV; 106 CFU/mouse lung, spleen, and liver N/A [96]
TNFα p55 receptor-/- IV; 106 CFU/mouse lung and spleen N/A [152]
Beige aerosolization; approximately 105 CFU/mouse lung and spleen CLR [100]
Beige IV; 106 CFU/mouse lung, spleen, liver, and gut N/A [90]
Nude aerosolization; approximately 105 CFU/mouse lung and spleen CLR, CLR-EMB-RIF, MXF-EMB-RIF, CLR-MXF-EMB-RIF [100]

Abbreviations: CFU, colony-forming units; CLR, clarithromycin; EMB, ethambutol; iNOS, inducible NO synthase; IV, intravenous; LAI, liposomal amikacin for inhalation; MXF, moxifloxacin; N/A, not applicable; NO, nitric oxide; RIF, rifampin; TNF, tumor necrosis factor.