Table 1. Function of selected conserved proteins identified in DE-cad ERC analysis.
*Score from flybase (www.flybase.org) orthologue database. Ratio indicates sequence alignment algorithms that reported significant homology with mammalian homologs.
| Protein | ERC value | Function in flies | Homolog(s) (score*) | Homolog function in mammals |
|---|---|---|---|---|
| Grk | 0.62 | Growth factor (EGF) | Nrg (1/15) | EGF family receptor ligand |
| Cac | 0.62 | Voltage-gated Ca2+ channel subunit |
Cacna1 (11/15) | Voltage-gated Ca2+ channel subunit |
| Hrb98DE | 0.54 | mRNA binding | Hnrnpa2b1 (13/15) | RNA binding protein |
| PDZ-GEF | 0.53 | Rap1 GEF | Rapgef2 (13/15) | Rap GEF |
| Rapgef6 (12/15) | ||||
| Rab5 | 0.52 | Rab GTPase; protein trafficking |
Rab5c (13/15) | Rab GTPase; protein trafficking |
| Rab5b (14/15) | ||||
| Stim | 0.52 | Ca2+ channel regulator | Stim1 (13/15) | Ca2+ influx regulation |
| Raskol CG42684 |
0.50 | GTPase activator activity (inferred) | Dab2ip (8/15) | Ras-GAP |
| Rasal2 (8/15) | Ras-GAP | |||
| Syngap1 (7/15) | Synaptic Ras-GAP | |||
| Babo | 0.5 | Activin (TGFβ) receptor | Tgfbr1 (14/15) | TGF-β receptor |
| Acvr1 (11/15) | ||||
| Gug | 0.49 | Nuclear repressor | Rere (10/15) | Transcriptional repressor |
| Pdk1 | 0.46 | Kinase; cell signaling | Pdpk1 (11/15) | Kinase; cell signaling |
| CG16952 | 0.46 | - | Btbd7 (10/15) | Branching morphogenesis |
| CG11593 | 0.46 | - | Bnip2 (6/15) | Rho GTPase signaling |
| CG14883 | 0.44 | - | Gde1 (12/15) | Glycerophosphodiester phosphodiesterase |