Table 3. Percentage of binding residues forming specific interactions with ligands.

Binding residues are identified by the class-activation map analysis to be part of the highly discriminative regions of nucleotide- and heme-binding pockets. Three types of interactions reported by the LPC program are considered, hydrogen bonds, aromatic and hydrophobic contacts.

Pocket type	Hydrogen	Aromatic	Hydrophobic
Nucleotide-binding	70.7%	4.8%	21.3%
Heme-binding	23.8%	12.9%	75.3%