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Riddelliine-induced cII MF as a function of dose. Big Blue rats were gavaged with 0.1–1.0 mg/kg body weight riddelliine for 12 weeks, and the cII MF was determined in the liver 1 day after the last treatment. The induced MF was obtained by subtracting the background MF observed in the vehicle control rats. The data represent the mean ± SD for each group of six rats.
