Table 1.

cII MFs in Livers of the Control and Riddelliine-Treated Transgenic Big Blue Rats

group	rat ID	total plaques screened (×103)	mutant plaques	MF (×10−6)	mean ± SD (×10−6)
control	I-1F	440	13	30
	I-2F	458	18	39
	I-3F	442	10	23
	I-4F	398	7	18
	I-5F	315	14	44
	I-6F	431	11	26
					30 ± 10
0.1 mg/kg	II-1F	379	12	32
	II-2F	392	16	41
	II-3F	531	22	41
	II-4F	269	18	67
	II-5F	295	11	37
	II-6F	245	15	61
					47 ± 14a
0.3 mg/kg	III-1F	570	33	58
	III-2F	378	20	53
	III-3F	359	18	50
	III-4F	393	24	61
	III-5F	216	14	65
	III-6F	378	16	42
					55 ± 8b
1.0 mg/kg	IV-1F	349	38	109
	IV-2F	399	31	78
	IV-3F	249	30	121
	IV-4F	271	29	107
	IV-5F	577	52	90
	IV-6F	387	43	111
					103 ± 16c,d

^aP < 0.05.

^bP < 0.01.

^cP < 0.001 (significantly higher than the control group, Tukey test).

^dSignificantly higher than the groups treated with 0.1 or 0.3 mg riddelliine per kg body weight (P < 0.01, Tukey test).