Table 3.

Summary of the Independent Mutations in the Liver cII Gene from the Ridelliine-Treated and Control Big Blue Rats

	controla		riddelliinea
type of mutation	number	%	number	%
G:C → C:G	2	4	4	5
G:C → A:T	30	55	22	26
G:C → T:A	5	9	29	35
A:T → T:A	3	5	4	5
A:T → C:G	3	5	5	6
A:T → G:C	3	5	4	5
frameshift	8	15	8	10
tandem base substitution	0	0	7	8
complexb	1	2	0	0
total	55	100	83	100

^aSpectra of mutations from control and riddelliine-treated rats significantly different [P < 0.001; Adams and Skopek test (13)].

^bBase substitution plus frameshift.