Figure 5:

(a) CTA showing a severely-calcified, high-grade stenosis (80–99%) at the carotid bifurcation in an 80-y.o. male generating a severe acoustic shadow (pink arrow in b). A highly-calcified white nodule was identified on the gross pathology image (blue dashed box in c), correlating with the echoreflective region of the plaque on the B-mode (red contour in b). The intra-plaque displacement (d) and strain (e) maps revealed regions of varying displacement and strain amplitude, while the intra-plaque PWV map showed a region of alternating positive and negative PWVs throughout the depth of the plaque at the distal end (white arrow in f).