TABLE 3.

Diagnostic Measures for Different Cortisol Thresholds at Different Time Points

Threshold	Sensitivity	Specificity	LR+	LR–	PPV	NPV
(nmol/L)	[95% CI]	[95% CI]	[95% CI]	[95% CI]	[95% CI]	[95% CI]
RR
700.0	81.8%	82.2%	4.6	.22	36.0%	97.4%
	[48.2-97.7]	[72.7-89.5]	[2.7-7.8]	[.06-.78]	[18.0-57.5]	[90.8-99.7]
744.0	90.9%	73.3%	3.4	.12	29.4%	98.5%
	[58.7-99.8]	[63.0-82.1]	[2.3-5.0]	[.02-.81]	[15.1-47.5]	[92.0-100]
757.5	100%	70.0%	3.3	.00	29.0%	100%
	[71.5-100]	[59.4-79.2]	[2.4-4.6]	[.00-.00]	[15.4-45.9]	[94.3-100]
Day 1
465.5	70.6%	82.4%	4.0	.36	35.3%	95.4%
	[44.0-89.7]	[74.6-88.6]	[2.5-6.5]	[.17-.75]	[19.8-53.5]	[89.5-98.5]
469.0	76.5%	81.6%	4.2	.29	36.1%	96.2%
	[50.1-93.2]	[73.7-88.0]	[2.6-6.5]	[.12-.68]	[20.8-53.8]	[90.6-99.0]
576.5	88.2%	70.4%	3.0	.17	28.9%	97.8%
	[63.6-98.5]	[61.6-78.2]	[2.2-4.1]	[.05-.62]	[17.1-43.1]	[92.2-99.7]
Day 2
385.5	76.9%	75.4%	3.1	.31	26.3%	96.6%
	[46.2-95.0]	[66.5-83.0]	[2.0-4.9]	[.11-.83]	[13.4-43.1]	[90.5-99.3]
416.5	84.6%	69.3%	2.8	.22	23.9%	97.5%
	[54.6-98.1]	[60.0-77.6]	[1.9-4.0]	[.06-.80]	[12.6-38.8]	[91.4-99.7]
440.5	92.3%	66.7%	2.8	.12	24.0%	98.7%
	[64.0-99.8]	[57.2-75.2]	[2.0-3.8]	[.02-.76]	[13.1-38.2]	[93.0-100]
Day 3
257.5	54.6%	89.6%	5.2	.51	46.2%	92.3%
	[23.4-83.3]	[79.7-95.7]	[2.2-12.6]	[.26-.97]	[19.2-74.9]	[83.0-97.5]
273.5	63.6%	88.1%	5.3	.41	46.7%	93.7%
	[30.8-89.1]	[77.8-94.7]	[2.4-11.7]	[.19-.91]	[21.3-73.4]	[84.5-98.2]
329.0	72.7%	82.1%	4.1	.33	40.0%	94.8%
	[39.0-94.0]	[70.8-90.4]	[2.2-7.6]	[.13-.88]	[19.1-64.0]	[85.6-98.9]

CI, confidence interval; LR+, positive likelihood ratio; LR–, negative likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; RR, recovery room.

The likelihood ratios refer to patients in the hypocortisolism group. The PPV also refers to patients in the hypocortisolism group.