Figure 3.

Mediation model for hypothesized pathway from baseline amygdalar metabolic activity to baseline visceral adiposity. A single mediator analysis demonstrated that bone marrow activity was a significant mediator [standardized β (95% CI) = 0.06 (0.007, 0.13); P = 0.007] of the relationship between baseline AmygA and baseline VAT, accounting for 48% of the total effect. Standardized regression coefficients are shown. Analyses included age and sex as covariates. a, effect of AmygA on bone marrow activity; b, effect of bone marrow activity on VAT; c, total effect of AmygA on VAT; c’, residual direct effect of AmygA on VAT (independent of mediated effects).