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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Anesthesiology. 2019 Mar;130(3):423–434. doi: 10.1097/ALN.0000000000002528

Figure 3: Astrocyte-specific knockout of Ndufs4 causes hysteresis between induction and emergence in TC. A.

Figure 3:

Δ Anesthetic Concentration, the change in the anesthetic concentration between induction and emergence, required to respond to tail clamp before and after exposure to ISO or HAL, at 3 weeks post injection of 4-hydroxy tamoxifen. N=6 for control, N=7 for the astrocyte-specific Ndufs4(KO). B. Δ Anesthetic Concentration required to respond to tail clamp before and after exposure to ISO or HAL, at 7 weeks post injection of 4-hydroxy tamoxifen. N=6 for control and the astrocyte-specific Ndufs4(KO). Tests for significance done on the difference between the EC50s for induction and emergence *** p<0.001. The error bars represent SD.