Table 1:

Effects of astrocyte-specific Ndufs4(KO) on anesthetic sensitivity for response to tail clamp.

	Tail Clamp-ISO Emerge/Induce				Tail Clamp-HAL Emerge/Induce
	Control		Astrocyte-specific Ndufs4(KO)		Control		Astrocyte-specific Ndufs4(KO)
	Induction	Emergence	Induction	Emergence	Induction	Emergence	Induction	Emergence
3 weeks	1.27±0.12	1.18±0.10	1.21±0.18	0.67±0.11*	1.28±0.05	1.08±0.09	1.20±0.05	0.59±0.12*
7 weeks	1.24±0.07	1.20±0.05	1.18±0.13	0.67±0.10*	1.19±0.04	1.15±0.10	1.22±0.07	0.66±0.10*

In each cell, bold numbers show the ratios of EC50s for emergence and induction for isoflurane or halothane, for control mice or astrocyte-specific Ndufs4(KO), at 3 weeks and 7 weeks post 4-hydroxytamoxifen injections. The endpoint used is response to tail clamp. The lower set of numbers in each cell are the measured values for the EC50s (emergence) and the EC50s (induction), respectively. p-values compare the KO ratio to the corresponding control ratio.

^* indicates p< 0.005. N=6 for controls, N≥6 for the astrocytic Ndufs4(KO).