Figure 7.

SCF receptor mutant W/W^v mice demonstrated the important role of the SCF-c-Kit activation during chronic allergic diseases. The lack of c-Kit signaling reduces the allergen-induced A) airway inflammation and mucus deposition in airway by histopathology, PAS staining B) qPCR of mucus-related genes Muc5 and Gob5, C) qPCR of lung cytokines IL-4 and IL-13 expression, D) decreased numbers of Mast cells, Eosinophils and ILC2 in the lung. Data represent mean ± SE from each group with 4 to 5 mice/group. All data are representative of two independent experiments. *P<0.05, **P<0.01, ***P<0.001