Fig. 1.

CCR4 expression on hematopoietic cells is necessary for MA-ARDS/ALI development. a Hemorrhagy (left quadrants) and permeability by evans blue dye (right quadrants) from lungs of uninfected controls (top quadrants) and C57BL/6 and CCR4^−/− mice 9 days post-infection (bottom quadrants). The bar graph indicates the quantification of evans blue infiltrated in the lungs. b Weights of lungs from WT and CCR4 knockout mice were determined at 9 days post-infection. c Histopathology scores, based on edema and inflammatory infiltrate were evaluated after H&E staining. d Parasitemia of C57BL/6 and CCR4^−/− mice. e Survival of PbN-infected C57BL6 and CCR4^−/− mice. f WT chimera mice reconstituted with bone marrow cells from CCR4^−/− or WT control (CCR4^+/+) mice. g CCR4^−/− chimera mice reconstituted with bone marrows from WT or CCR4^−/− mice. Data are representative of at least two independent experiments (n = 4–6 mice per group)