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. 2019 Feb 8;10:66. doi: 10.3389/fendo.2019.00066

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Copyright © 2019 Darras.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maternal TH supply to the developing brain of a 4-day-old chicken embryo is regulated at 4 different levels. The factors controlling TH transport and metabolism (TH distributor proteins, TH transporters, deiodinases) shown to be present at E4 at the different levels are mentioned. ALB: albumin, BBB: blood-brain-barrier, DIO1-3: deiodinase 1-3, LAT1: L-type amino acid transporter 1, MCT8-10: monocarboxylate transporter 8-10, OATP1C1: organic anion transporting protein 1C1, TTR: transthyretin.