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. 2019 Feb 8;10:29. doi: 10.3389/fneur.2019.00029

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Copyright © 2019 Di Giulio, Kalliolia, Georgiev, Peters, Voyce, Akram, Foltynie, Limousin and Day.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of relative effects of changing frequency and voltage on gait variables. (A) Representative patient's mean stride velocity data at each of four STN-DBS settings. The same data are arranged differently to show the mean effect of changing voltage (left) and the mean effect of changing frequency (right). For this patient, the change in stride velocity was larger when changing frequency from 120 to 80 Hz compared to a change in voltage from a high (4.3 and 5.2 V left and right electrodes respectively) to a low value (3.5 and 4.2V left and right electrode respectively). (B) All patients' frequency (Δ_Freq) and voltage (Δ_Volt) effects for each gait variable. The change due to Δ_Freq was significantly (p < 0.05) larger than the change due to Δ_Volt for stride velocity, stride length and double-support time.