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. 2019 Feb 8;13:30. doi: 10.3389/fncel.2019.00030

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Copyright © 2019 Yu, Li, Zhang, Pan, Yu, Zhang, Zheng, Si and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The antidepressant- (A,C) and anxiolytic-like (B,D) effects of resveratrol in irritable bowel syndrome (IBS) rats were involved in 5-HT_1A receptor. Values are expressed as mean ± SEM (n = 6–8, per group), ***P < 0.001 vs. vehicle-treated control group (“Veh + Ctrl” group); ^###P < 0.001 vs. vehicle-treated CACS group (“Veh + CACS” group); ^$P < 0.05, ^$$$P < 0.001 vs. 10 mg/kg resveratrol-treated CACS group (“RES 10 + CACS” group); ^&P < 0.05, ^&&P < 0.01 vs. 40 mg/kg resveratrol-treated CACS group (“RES 40 + CACS” group).