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. 2019 Feb 8;13:4. doi: 10.3389/fncel.2019.00004

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Copyright © 2019 Montroull, Danelon, Cragnolini and Mascó.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sequestering BDNF prevents TrkB signaling. TrkB-Fc was infused in the hippocampi of one hemisphere (ipsilateral, i) of control and SE animals. The dorsal hippocampus from non-infused side (c) and infused side (i) were homogenized separately and analyzed by western blot to determine BDNF (A), proBDNF (C), TrkB (D) and pTrkB (E). Panels (B,F,G) show the quantifications for BDNF (B), TrkB (F) and pTrkB (G). Black bars represent non-infused hippocampus and gray bars TrkB-Fc infused sides. Results are expressed as mean ± SEM of four animals per treatment. Asterisks indicate p < 0.05 by two-way ANOVA followed by Tukey’s post hoc analysis.