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. 2019 Feb 8;10:207. doi: 10.3389/fmicb.2019.00207

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Copyright © 2019 Ito, Nakashima, Sun, Ito and Suzuki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of deletions in intron region of the HBV genome on the splicing efficiency in human HCC and non-hepatic cells. RT-PCR analyses of HBV RNAs expressed from WT and deletion-mutants corresponding to D1 and D4 derived from GT-A (deleted regions; nt 2990–3202 in D1, nt 2864-48 in D4), -C (nt 2984–3196 in D1, nt 2858-48 in D4) and -D (nt 2951–3163 in D1, nt 2858-48 in D4) in human HCC (HepG2, HuH-7 and PLC/PRF/5) cells (A) and in non-hepatic (HEK293, A549, and HeLa) cells (B). Sp ratio; the quantity ratio of the spliced RNAs to the unspliced RNA. Open arrows, unspliced forms.