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. 2019 Feb 8;10:170. doi: 10.3389/fimmu.2019.00170

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Copyright © 2019 Vacca, Chiossone, Mingari and Moretta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative ILC development and cytokine production. Common lymphoid progenitors (CLPs) differentiate into common innate lymphoid precursors (CILPs) that can further give rise to common helper innate lymphoid precursors (CHILPs) or into NK precursors (NKPs). CHILPs give rise to LTi precursors (LTiPs) that differentiate into LTi cells or to ILC precursors (ILCPs) that differentiate into ILC1s, ILC2s, and ILC3s, while NKPs differentiate toward NK cells. Specific transcription factors (TFs) required step are indicated.