Table 1.
Various classes of NMDAR antagonists.
| Mechanism of NMDAR antagonists | Examples | IC50 | Key reference |
|---|---|---|---|
| GluN2B | |||
| Non-competitive | Ifenprodil | 0.34 μM | Williams, 1993 |
| CP-101,606 | 10 nM | Chenard et al., 1995 | |
| Ro 25-6981 | 0.003 μM | Fischer et al., 1997 | |
| GluN2A | |||
| Non-competitive | Zinc | 5.0 ± 1.6 nM | Chen et al., 1997 |
| GluN2D | |||
| NAB-14 | 580 nM | Swanger et al., 2017 | |
| GluN3 | |||
| Non-competitive | TK13 | 67 μM (GluN3A) 49 μM (GluN3B) | Kvist et al., 2013 |
| TK30 | 14 μM (GluN3A) 7.4 μM (GluN3B) | Kvist et al., 2013 | |
| GluN3B | |||
| Competitive | TK80 | 79 μM | Kvist et al., 2013 |