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. 2019 Feb 14;9:2049. doi: 10.1038/s41598-018-38425-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of MG132 on the NF-κB level in DN rats. In DN rats, the relative mRNA level of NF-κB was significantly higher than in NC rats and was reduced after the administration of MG132 and deguelin for the indicted time (A). Likewise, the level of p65 was significantly higher than in NC rats and was reduced after administration of MG132 and deguelin for the indicted time (B). NC: normal control group; DN: diabetic nephropathy group; MG132: diabetic nephropathy plus MG132 treatment group; Deguelin: diabetic nephropathy plus deguelin treatment group. Means ± SEM; N = 6; *P < 0.05 vs. NC; ^#P < 0.05 vs. DN.