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. 2019 Feb 14;9:2065. doi: 10.1038/s41598-019-38559-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sgroppino mutants are hypersensitive to RNA virus infection. (A) Survival upon DCV infection of flies ubiquitously expressing an RNAi-inducing hairpin targeting Sgp. The ubiquitous Actin driver line (Actin-Gal4) was used to drive expression of the transcription factor Gal4, which binds the Upstream Activating Sequence to induce expression a short hairpin RNA targeting Sgp (UAS-Sgp^RNAi). Flies expressing the Actin-Gal4 driver, but not the UAS responder (Actin-Gal4>+), were included as controls. (B–F) Survival of wild-type (y¹w¹) and Sgp^−/− mutant flies upon (B) DCV, (C) CrPV, (D) FHV, (E) DXV and (F) IIV-6 infection. Data represent means and s.d. of three biological replicates of at least 15 female flies for each genotype.