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. 2019 Feb 14;9:2038. doi: 10.1038/s41598-018-38432-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lack of PD-L1 altered gene expression profile of Tregs. (A) Foxp3⁺ Tregs were isolated by FACS from naive and nephritic FIR-tiger-PD-L1^−/− and FIR-tiger mice. Representative dot plots show sorting strategy and purity of isolated Tregs. (B) NanoString analysis was done with FACS-isolated Tregs from naive and nephritic FIR-tiger-PD-L1^−/− and FIR-tiger mice. Heatmap of immunological gene expression in Tregs is shown. (C) Relative gene expression levels of Tregs from naive and nephritic FIR-tiger-PD-L1^−/− and FIR-tiger mice are shown. Columns and bar graphs show mean values of three independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001; ns, not significant; Pdcd1: PD-1; Il2ra: IL-2 receptor subunit alpha; Entpd1: CD39; Gzmb: granzyme B; Csf1: colony stimulating factor 1.