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. 2019 Feb 14;9:89. doi: 10.1038/s41398-019-0384-y

Fig. 1. Top genes, pathways and networks from differential gene expression in DLFPC region from 68 alcoholics and 70 controls.

Fig. 1

a Volcano plot showing top differentially expressed genes among cases and controls. b The genes passing FDR threshold of 20% were inputted to IPA for pathway enrichment analysis. The figure shows some of the top pathways identified by IPA. P values here are from right tail Fisher’s exact test. c Enrichment analysis of gene ontology “biological process” terms. Color depicts the qvalues with red being the strongest evidence of enrichment. d Network analysis on top genes (FDR < =20%) mapped to networks involved in the neurodegenerative disorders and organismal injuries. P value under the gene is the uncorrected p value for differential expression among alcoholics and controls. The nominally significant genes in the UKBB-alc and PGC-SUD GWAS are highlighted with purple border and blue annotation