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. 2019 Feb 14;51(2):16. doi: 10.1038/s12276-019-0214-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — State III myocardial respiration on octanoyl-carnitine (a, c) and on the citrate cycle-derived substrates glutamate and succinate (b, d) and mRNA expression of NDUFS1 and CPT1B in myocardial tissue specimens from patients suffering from terminal heart failure and heart transplant recipients. a, b Comparison of maximal myocardial respiration. Student's t-test. c, d Correlation of maximal myocardial respiration and cardiac index measurements. Spearman correlation. e, f Expression of NDUFS1 and CPT1B mRNA. Student's t-test. n = 40 (HF, patients suffering from terminal heart failure; n = 4 in mRNA measurements), n = 29 (HTX, heart transplant recipients; n = 21 in mRNA measurements). AU arbitrary unit. ***p < 0.001, ****p < 0.0001