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. 2019 Feb 14;9:2133. doi: 10.1038/s41598-019-38603-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolic activity. (A) Phosphorylated (Ser235/236) S6 ribosomal protein was used as a marker for the activity of mTOR, a master regulator of cellular metabolism. Positivity for S6 phosphorylation in all tissue slices at all time points indicates continued metabolic activity. (B) Quantitation of pS6 staining intensity in cancerous cells at different time points from the cases depicted in (A). (C) Comparative assessment of metabolic activity (average pS6 staining intensity, n = 5) of cancerous cells in cultured slices over the entire duration of culture (Friedman test followed by Dunn’s multiple comparison; p ≤ 0.05). * indicates significant difference between the given time points.