Table 5.
Predicted QTL effects and potential genetic improvement from marker-assisted selection (MAS) for traits GNL, OS-C, 3′-SL and OS-B.
| Chromosome: Position | OS | MAFa in this study (N = 332) |
MAF in general Holstein population (N = 37678) |
Effect size (arbitrary unit) | Current genetic average in populationb | Potential genetic average from MASc | Potential genetic improvement (fold) from MASd |
|---|---|---|---|---|---|---|---|
| Chr11: 104229609 |
GNL | 0.35 | 0.39 | 4724310 | 3684962 | 9448620 | 2.6 |
| Chr11: 104229609 |
OS-C | 0.35 | 0.39 | 247826 | 193304 | 495652 | 2.6 |
| Chr1: 42593589 |
3′-SL | 0.23 | 0.22 | 1062120 | 467333 | 2124240 | 4.5 |
| Chr16: 53653341 |
OS-B | 0.12 | 0.16 | 103766 | 33205 | 207532 | 6.3 |
| Chr10: 6491671 |
OS-B | 0.42 | 0.55 | 62639 | 68903 | 125278 | 1.8 |
| Chr26: 36764962 |
OS-B | 0.06 | 0.06 | 132046 | 15846 | 264092 | 16.7 |
aMAF: Minor Allele Frequency.
bGenetic average based on the marker effect and Hardy-Weinberg equilibrium genotype frequencies in the general Holstein population.
cPotential average based on selection for the entire herd carrying only the favourable alleles.
dDifference between the current genetic average due to the favourable mutation and the potential genetic average if all animals were selected to carry 2 copies of the favourable alleles.