Fig. 2.

Overview of the HAdV-D26 and HAdV-D48 fiber-knob protein structures. The surface representation of the trimeric HAdV-D26K (PDB 6FJN) biological assembly is shown side-on with the cartoon representation shown for the nearest monomer (a) and the top-down view of the same HAdV-D26K trimer, as it would appear looking towards the virion, is seen as a cartoon representation (b), with each monomer coloured in red, green, or blue with the hypervariable loops extending between the β-strands (dark blue) coloured as follows: AB—green, BC—purple, CD—brown, DE—orange, DG—red, EG—pink, GH—purple, HI—yellow, IJ—light blue. The HAdV-D48K (PDB 6FJQ) trimer is shown similarly (c, d). The Wu–Kabat variability plot of the fiber-knob domains of species D adenoviruses shows regions of low variability (e) with the locations of the HAdV-D48K β-strands shown by arrows above the graph, and the positions coloured blue, or red when the position is a β-strand in both HAdV-D26K and HAdV-D48K