Fig. 4.

Hypervariable loop conformations and contacts residues. The residues comprising the indicated loops of HAdV-D26K (a) and HAdV-D48K (b) are shown diagrammatically with numbers indicating the start and end residues of each loop depicted. The network of intraloop polar interactions is shown by solid lines (one polar bond), and dashed lines (two polar bonds, colour variations are only for ease of viewing) between interacting residues, similar interloop bonds are also present as visualised in Supplementary Figure 2. Residues forming part of a helical motif are shaded in blue. The HAdV-D48K DG-loop is seen to form contacts to the opposing monomer across the inter-monomeric cleft (c). The labelled residues forming polar contacts (shown as sticks) are coloured by relative B-factor, with warmer colours indicating higher relative B-factors, as is the cartoon representation of the loop. The opposing HAdV-D48K monomer is seen as a ribbon representation of the carbon-α chain in cyan and the surface of the HAdV-D48K trimer seen as a semi-transparent grey surface