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. 2019 Feb 14;9:2018. doi: 10.1038/s41598-018-38336-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LPS mediated increase in invasion was prevented by inhibition of NF-κB activity. (A) HTR-8/SVneo cells were stained for assessing the expression of integrins α1 and α6. Graph shows mean staining intensity for α1 and α6 across groups. (B) Graph shows the average number of cells counted in the lower chamber in the matrigel invasion assay with HTR-8/SVneo cells treated with LPS + NF-κB inhibitor. (C) Graph shows mean length of invasion in different groups measured after 24 hrs of treatment showing reduction in LPS induced invasion in presence of NF-κB inhibitor. (D) Representative image showing effects of NF-κB inhibitor on invasion in explant villous clusters with EVT tips. n = 4, ^{‘*’, ‘ψ’} indicates significance at p < 0.05 when compared to the PBS control group for α1 and α6 respectively, ^{‘#’, ‘¥’} indicates significance at p < 0.05 when compared to the LPS treated group for α1 and α6 respectively.