Figure 2. Pulmonary haemodynamics and lung nitric oxide release.

Time course of mean pulmonary arterial pressure (MPAP) (A), mean pulmonary vascular resistance (PVR) (B), and nitric oxide release rate (NO release) (C), Measurements were performed continuously and values were obtained in 30 min intervals during 1 h of hyperoxia ($F_{\mathrm{I},{\mathrm{o}}_2}$ = 0.5) and during 3 h of isobaric hypoxia ($F_{\mathrm{I},{\mathrm{o}}_2}$ = 0.145–0.12) in control animals (n = 8), and pigs treated with i.v. ACZ (n = 7), inhaled NaNO₂ (n = 6) and combined i.v. ACZ + iNaNO₂ (n = 6). Values are means ± SD. ^* P < 0.05 vs. hyperoxia; ^† P < 0.05 vs. controls.