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. 2018 Oct 13;74(3):315–324. doi: 10.1093/gerona/gly237

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Published by Oxford University Press on behalf of The Gerontological Society of America 2018.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 2. — Aging is associated with changes in kidney function in marmosets and they correlate with histological changes. (A and B) Urinary albumin to creatinine ratio (UACR) and urinary protein to creatinine ratio (UPCR) data in aged marmosets and young marmosets are shown. (C) Immunoblotting of kidney cortical lysates showed reduction in the expression of nephrin in aged marmosets (Y = young, A = aged). Data in A–C are shown as mean ± SEM, n = 4 young male and n = 3–4 young female marmosets, n = 5 aged male and n = 5 aged female marmosets (**p < .01 vs young male; ^##p < .01 vs young female by two-way ANOVA). Correlation between glomerular injury (G. Injury) and tubular fibrosis (T. Fibrosis) indices and UACR, UPCR was studied. (D and E) A high degree of correlation existed between glomerular injury and UACR (r = .78, *p = .0172), and UPCR (r = .80, *p = .0138) in aged males; a trend toward correlation between glomerular injury and UPCR (r = .68, p = .0694) but not UACR (r = .58, p = .1080) was seen in aged females. (F and G) A strong negative relationship was present between nephrin expression and UACR (r = −0.88, *p = .0031) and UPCR (r = −.70, *p = .0433) in aged males; in aged females, a negative correlation was present between nephrin and UPCR (r = −0.81, *p = .0218) and a trend with UACR (r = −0.65, p = .0666). (H and I) In aged males, tubular fibrosis did not have a significant relationship with UACR (r = .25, p = .5206) or UPCR (r = .38, p = .3125); in aged females a trend was seen with UACR (r = .67, p = .0589) but not with UPCR (r = .51, p = .1966).