Table 2.
Pathogen Identification for the 175 Patients of 216 With Laboratory Diagnoses, Recruited to a Murine Typhus Clinical Trial
Pathogen | Patients, No. | |||
---|---|---|---|---|
Total | Culture | PCR | Serology | |
Rickettsia typhi | 158a,b | NA | 53a | 155b |
Orientia tsutsugamushi | 7 | NA | 6 | 4 |
Salmonella enterica Typhic | 5 | 5 | NA | NA |
Leptospira spp. | 4 | NA | 4a | NA |
Escherichia coli c | 1 | 1 | NA | NA |
Salmonella enterica Paratyphi Ac | 1 | 1 | NA | NA |
Abbreviations: NA, not applicable; PCR, polymerase chain reaction.
aOne patient was PCR positive for both R. typhi and Leptospira sp.
bA total of 160 patients had serologic evidence of R. typhi infection, but 5 had PCR/culture evidence of another pathogen (E. coli, Salmonella Typhi, and Leptospira sp. in 1 each and O. tsutsugamushi in 2). They may have had concurrent dual infections, but we have opted to be conservative and not included these 5 patients, giving a denominator of 155 patients.
cBlood culture and bacterial identification as described by Phetsouvanh et al [21].