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. 2018 Jul 18;68(5):757–772. doi: 10.1093/cid/ciy562

Table 1.

Studies Reporting Herpes Simplex Virus Type 1 Seroprevalence Among Different Populations in Asia

Authors (Year) Year(s) of Data Collection Country Study Site Study Design Sampling Method Population HSV-1 Serological Assay Sample Size, No. HSV-1 Seroprevalence, %
Healthy Children Populations (n = 19)
Bogaerts et al (2001) [49] 1996–1998 Bangladesh Outpatient clinic CS Conv 1–12-y-old children WB 79 46.0
Chang (1986) [50] 1984–1986 China Hospital CS Conv 7–12-mo-old infants CFT 31 41.9
Chang (1986) [50] 1984–1987 China Hospital CS Conv 13–24-mo-old children CFT 31 51.6
Chang (1986) [50] 1984–1988 China Hospital CS Conv 24–35-mo-old children CFT 30 43.3
Chang (1986) [50] 1984–1989 China Hospital CS Conv 3–4-y-old children CFT 31 67.7
Chang (1986) [50] 1984–1990 China Hospital CS Conv 5–6-y-old children CFT 31 48.4
Chang (1986) [50] 1984–1991 China Hospital CS Conv 7–8-y-old children CFT 31 71.0
Chang (1986) [50] 1984–1992 China Hospital CS Conv 9–14-y-old children CFT 31 74.2
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 1-y-old children ELISA 90 11.1
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 2-y-old children ELISA 127 14.2
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 3-y-old children ELISA 92 31.5
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 4-y-old children ELISA 84 23.8
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 5–9-y-old children ELISA 111 46.8
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 10–14-y-old children ELISA 92 46.7
Li et al (1990) [52] 1988–1989 China Community CS Conv 1–10-y-old Koreans PHA 16 38.0
Lin et al (2011) [53] 2006 China Community CS RS 5–9-y-old girls ELISA 40 64.9
Lin et al (2011) [53] 2006 China Community CS RS 10–14-y-old girls ELISA 45 78.3
Lin et al (2011) [53] 2006 China Community CS RS 5–9-y-old boys ELISA 75 59.8
Lin et al (2011) [53] 2006 China Community CS RS 10–14-y-old boys ELISA 64 78.0
Healthy Adult Populations (n = 103)
Armelia et al (2012) [54] 2010–2011 Indonesia Hospital CSa Conv Kidney donors Anti-HSV-1 IgG 23 72.7
Ashley et al (2004) [55] 2000–2001 Thailand Community CS Conv ≥15-y-old women in Lampang WB 98 92.9
Ashley et al (2004) [55] 2000–2001 Thailand Community CS Conv ≥15-y-old women in Songkla WB 90 61.1
Ashley et al (2004) [55] 2000–2001 Vietnam Community CS Conv ≥15-y-old women in Hanoi WB 99 100.0
Ashley et al (2004) [55] 2000–2001 Vietnam Community CS Conv ≥15-y-old women in Ho Chi Minh WB 100 98.0
Bogaerts et al (2001) [49] 1996–1998 Bangladesh Outpatient clinic CS Conv Healthy women ELISA 183 97.0
Bu et al (2015) [45] 2012–2013 China Hospital CC Conv Healthy individuals ELISA 135 78.5
Chang (1986) [50] 1984–1986 China Hospital CS Conv >14-y-old adults CFT 30 93.3
Cowan et al (2003) [56] 1998–2000 India Community CS Conv 15–20-y-old adults ELISA 239b 85.7
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 15–19-y-old adults ELISA 115 53.0
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 20–29-y-old adults ELISA 123 69.9
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 30–39-y-old adults ELISA 129 84.5
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 40–49-y-old adults ELISA 100 94.0
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 50–59-y-old adults ELISA 91 98.9
Chen et al (2013) [51] 2007 Taiwan Community CS Conv 60–69-y-old adult ELISA 122 100
Chen et al (2013) [51] 2007 Taiwan Community CS Conv >70-y-old adults ELISA 96 100
Cowan et al (2003) [56] 1998–2000 India Community CS Conv 20–30-y-old adults ELISA 239b 79.9
Cowan et al (2003) [56] 1998–2000 India Community CS Conv 30–35-y-old adults ELISA 239b 80.0
Cowan et al (2003) [56] 1998–2000 India Community CS Conv 25–40-y-old adults ELISA 239b 84.8
Cowan et al (2003) [56] 1998–2000 India Community CS Conv 40–45-y-old adults ELISA 239b 86.2
Cowan et al (2003) [56] 1998–2000 India Community CS Conv >45-y-old adults ELISA 239b 92.5
Doi et al (2009) [57] 2002 Japan Community CSa RS 18–29-y-old women ELISA 83 45.8
Doi et al (2009) [57] 2002 Japan Community CSa RS 30–39-y-old women ELISA 184 50.5
Doi et al (2009) [57] 2002 Japan Community CSa RS 40–49-y-old women ELISA 198 66.7
Doi et al (2009) [57] 2002 Japan Community CSa RS 50–59-y-old women ELISA 200 79.0
Doi et al (2009) [57] 2002 Japan Community CSa RS 18–29-y-old men ELISA 45 44.4
Doi et al (2009) [57] 2002 Japan Community CSa RS 30–39-y-old men ELISA 129 44.2
Doi et al (2009) [57] 2002 Japan Community CSa RS 40–49-y-old men ELISA 198 49.0
Doi et al (2009) [57] 2002 Japan Community CSa RS 50–59-y-old men ELISA 198 71.7
Hashido et al (1998) [58] NA Japan Community CS Conv <30-y-old men blood donors EIA 12 33.0
Hashido et al (1998) [58] NA Japan Community CS Conv 30–50-y-old men blood donors EIA 17 70.0
Hashido et al (1998) [58] NA Japan Community CS Conv >50-y-old men blood donors EIA 12 92.0
Hashido et al (1998) [58] NA Japan Community CS Conv 20–39-y-old healthy women EIA 20 65.0
Hashido et al (1998) [58] NA Japan Community CS Conv 40–99-y-old healthy women EIA 28 89.0
Hashido et al (1998) [58] NA Japan Community CS Conv >50-y-old healthy women EIA 27 92.5
Hashido et al (1998) [58] NA Japan Community CS Conv Pregnant women from Tokyo EIA 58 47.0
Hashido et al (1998) [58] NA Japan Community CS Conv Pregnant women from Kagoshima EIA 100 61.0
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 20–29-y-old men in 1973 ELISA 31 64.5
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 30–39-y-old men in 1973 ELISA 25 76.0
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 40–49-y-old men in 1973 ELISA 15 86.7
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 20–29-y-old men in 1983 ELISA 24 37.5
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 30–39-y-old men in 1983 ELISA 30 76.7
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 40–49-y-old men in 1983 ELISA 33 90.9
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 20–29-y-old men in 1993 ELISA 30 33.3
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 30–39-y-old men in 1993 ELISA 30 56.7
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 40–49-y-old men in 1993 ELISA 45 75.6
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 20–29-y-old women in 1973 ELISA 32 59.4
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 30–39-y-old women in 1973 ELISA 33 84.8
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 40–49-y-old women in 1973 ELISA 23 100.0
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 20–29-y-old women in 1983 ELISA 35 51.4
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 30–39-y-old women in 1983 ELISA 36 77.8
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 40–49-y-old women in 1983 ELISA 34 97.1
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 20–29-y-old women in 1993 ELISA 63 31.7
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 30–39-y-old women in 1993 ELISA 54 69.1
Hashido et al (1999) [59] 1973–1993 Japan Community CS Conv 40–49-y-old women in 1993 ELISA 41 80.5
Kaur et al (1999) [60] NA India Outpatient clinic CS Conv 16–20-y-old pregnant women EIA 24 50.0
Kaur et al (1999) [60] NA India Outpatient clinic CS Conv 21–25-y-old pregnant women EIA 36 44.4
Kaur et al (1999) [60] NA India Outpatient clinic CS Conv 26–30-y-old pregnant women EIA 34 55.8
Kaur et al (1999) [60] NA India Outpatient clinic CS Conv 31–35-y-old pregnant women EIA 14 14.1
Kaur et al (1999) [60] NA India Outpatient clinic CS Conv >36-y-old pregnant women EIA 12 83.3
Kaur et al (2005) [61] NA India Outpatient clinic CS Conv 16–20-y-old women ELISA 12 50.0
Kaur et al (2005) [61] NA India Outpatient clinic CS Conv 21–25-y-old women ELISA 17 47.1
Kaur et al (2005) [61] NA India Outpatient clinic CS Conv 26–30-y-old women ELISA 18 50.0
Kaur et al (2005) [61] NA India Outpatient clinic CS Conv 31–40-y-old women ELISA 13 46.1
Kaur et al (2005) [61] NA India Outpatient clinic CS Conv 16–20-y-old men ELISA 13 46.1
Kaur et al (2005) [61] NA India Outpatient clinic CS Conv 21–25-y-old men ELISA 20 25.0
Kaur et al (2005) [61] NA India Outpatient clinic CS Conv 26–30-y-old men ELISA 14 71.4
Kaur et al (2005) [61] NA India Outpatient clinic CS Conv 31–40-y-old men ELISA 13 46.1
Li et al (1990) [52] 1988–1989 China Community CS Conv >21-y-old Hans Chinese PHA 78 99.0
Li et al (1990) [52] 1988–1989 China Community CS Conv >21-y-old Koreans PHA 34 97.0
Lin et al (2011) [53] 2006 China Community CS RS 15–19-y-old women ELISA 78 87.5
Lin et al (2011) [53] 2006 China Community CS RS 20–24-y-old women ELISA 101 86.1
Lin et al (2011) [53] 2006 China Community CS RS 25–29-y-old women ELISA 135 93.3
Lin et al (2011) [53] 2006 China Community CS RS 30–34-y-old women ELISA 152 96.7
Lin et al (2011) [53] 2006 China Community CS RS 35–39-y-old women ELISA 154 95.5
Lin et al (2011) [53] 2006 China Community CS RS 40–44-y-old women ELISA 129 98.4
Lin et al (2011) [53] 2006 China Community CS RS 45–49-y-old women ELISA 97 98.0
Lin et al (2011) [53] 2006 China Community CS RS 50–54-y-old women ELISA 101 98.1
Lin et al (2011) [53] 2006 China Community CS RS 55–60-y-old women ELISA 44 97.8
Lin et al (2011) [53] 2006 China Community CS RS 15–19-y-old men ELISA 89 76.5
Lin et al (2011) [53] 2006 China Community CS RS 20–24-y-old men ELISA 93 81.9
Lin et al (2011) [53] 2006 China Community CS RS 25–29-y-old men ELISA 112 86.5
Lin et al (2011) [53] 2006 China Community CS RS 30–34-y-old men ELISA 137 90.4
Lin et al (2011) [53] 2006 China Community CS RS 35–39-y-old men ELISA 144 93.7
Lin et al (2011) [53] 2006 China Community CS RS 40–44-y-old men ELISA 118 97.4
Lin et al (2011) [53] 2006 China Community CS RS 45–49-y-old men ELISA 89 96.7
Lin et al (2011) [53] 2006 China Community CS RS 50–54-y-old men ELISA 82 98.7
Lin et al (2011) [53] 2006 China Community CS RS 55–60-y-old men ELISA 62 98.4
Nasrallah GK, Dargham SR, Harfouche M, and Abu-Raddad LJ (2018, unpublished data) 2013–2016 India Community CS Conv <24-y-old Indian men ELISA 40 40.0
Nasrallah GK, Dargham SR, Harfouche M, and Abu-Raddad LJ (2018, unpublished data) 2013–2016 India Community CS Conv 25–29-y-old Indian men ELISA 49 34.0
Nasrallah GK, Dargham SR, Harfouche M, and Abu-Raddad LJ (2018, unpublished data) 2013–2016 India Community CS Conv 30–34-y-old Indian men ELISA 50 60.0
Nasrallah GK, Dargham SR, Harfouche M, and Abu-Raddad LJ (2018, unpublished data) 2013–2016 India Community CS Conv 35–39-y-old Indian men ELISA 50 36.0
Nasrallah GK, Dargham SR, Harfouche M, and Abu-Raddad LJ (2018, unpublished data) 2013–2016 India Community CS Conv 40–44-y-old Indian men ELISA 50 48.0
Nasrallah GK, Dargham SR, Harfouche M, and Abu-Raddad LJ (2018, unpublished data) 2013–2016 India Community CS Conv 45–49-y-old Indian men ELISA 50 58.0
Nasrallah GK, Dargham SR, Harfouche M, and Abu-Raddad LJ (2018, unpublished data) 2013–2016 India Community CS Conv >50-y-old Indian men ELISA 35 62.0
Nasrallah GK, Dargham SR, Harfouche M, and Abu-Raddad LJ (2018, unpublished data) 2013–2016 Philippines Community CS Conv <34-y-old Filipino men ELISA 52 84.6
Nasrallah GK, Dargham SR, Harfouche M, and Abu-Raddad LJ (2018, unpublished data) 2013–2016 Philippines Community CS Conv 35–44-y-old Filipino men ELISA 40 82.5
Nasrallah GK, Dargham SR, Harfouche M, and Abu-Raddad LJ (2018, unpublished data) 2013–2016 Philippines Community CS Conv >45-y-old Filipino men ELISA 28 85.7
Patnaik et al (2007) [62] 1985–2007 Thailand Hospital CC Conv Healthy women WB 78 51.3
Schmid et al (1999) [63] 1991–1993 Thailand Hospital CS Conv >21-y-old army men WB 1158 77.9
Shivaswamy et al (2005) [64] 2001–2003 India Outpatient clinic CC Conv Healthy individuals ELISA 135 91.8
Yue (1990) [65] 1987–1989 China Outpatient clinic CS Conv Pregnant women ELISA 295 82.0
Zegans et al (1999) [66] 1997 India Hospital CC Conv Controls for a study of Mooren ulcer ELISA 44 64.0
Healthy Mixed-Age Populations (n = 4)
Li et al (1990) [52] 1988–1989 China Community CS Conv 11–20-y-old Hans Chinese PHA 17 94.1
Li et al (1990) [52] 1988–1989 China Community CS Conv 11–20-y-old Koreans PHA 13 85.0
Shen et al (2015) [67] 2007 Taiwan Community CS RS Healthy women ELISA 830 64.5
Shen et al (2015) [67] 2007 Taiwan Community CS RS Healthy men ELISA 581 52.0
Clinical Children Populations (n = 7)
Cowan et al (2003) [56] 1998–2000 India Hospital CS Conv 1–5-y-old children ELISA 90b 40.2
Cowan et al (2003) [56] 1998–2000 India Hospital CS Conv 5–10-y-old children ELISA 90b 68.4
Cowan et al (2003) [56] 1998–2000 India Hospital CS Conv 10–15-y-old children ELISA 90b 75.9
Cowan et al (2003) [56] 1998–2000 Sri Lanka Hospital CS Conv 1–5-y-old children ELISA 144b 40.5
Cowan et al (2003) [56] 1998–2000 Sri Lanka Hospital CS Conv 5–10-y-old children ELISA 144b 53.1
Cowan et al (2003) [56] 1998–2000 Sri Lanka Hospital CS Conv 10–15-y-old children ELISA 144b 74.0
Shymala et al (2008) [68] 2005–2006 India Outpatient clinic CS Conv Infants with congenital cataract ELISA 18 16.7
Clinical Adult Populations (n = 23)
Armelia et al (2012) [54] 2010–2011 Indonesia Hospital CSa Conv Pre–kidney transplant patients Anti-HSV-1 IgG 23 68.2
Bu et al (2015) [45] 2012–2013 China Hospital CC Conv Patients with Alzheimer disease ELISA 128 85.2
Hashido et al (1998) [58] NA Japan Community CS Conv <39-y-old patients with STD EIA 10 60.0
Hashido et al (1998) [58] NA Japan Community CS Conv >40-y-old patients with STD EIA 16 81.2
Hashido et al (1998) [58] NA Japan Community CS Conv Pregnant Tokyo women with HTLV-1 EIA 32 56.0
Hashido et al (1998) [58] NA Japan Community CS Conv Pregnant Kagoshima women with HTLV-1 EIA 100 83.0
Kaur et al (2006) [69] NA India Outpatient clinic CS Conv Women attending an STD clinic ELISA 52 82.7
Kaur et al (2006) [69] NA India Outpatient clinic CS Conv Women attending an STD clinic ELISA 76 73.7
Patwardhan and Bhalla (2016) [70] NA India Hospital CS Conv Patients with first genital herpes ELISA 21 42.8
Patwardhan and Bhalla (2016) [70] NA India Hospital CS Conv Patients with recurrent genital herpes ELISA 23 65.2
Shivaswamy et al (2005) [64] 2001–2003 India Outpatient clinic CC Conv <40-y-old patients in an STI clinic ELISA 111 90.1
Shivaswamy et al (2005) [64] 2001–2003 India Outpatient clinic CC Conv ≥40-y-old patients in an STI clinic ELISA 24 95.8
Sun et al (2005) [48] NA China Hospital CS Conv Diabetic inpatients ELISA 206 46.1
Sun et al (2005) [48] NA China Hospital CS Conv Nondiabetic inpatients ELISA 1360 36.3
Theng et al (2006) [71] 2003–2004 Singapore Outpatient clinic CS Conv <29-y-old men ELISA 72 47.2
Theng et al (2006) [71] 2003–2004 Singapore Outpatient clinic CS Conv 30–39-y-old men ELISA 50 52.0
Theng et al (2006) [71] 2003–2004 Singapore Outpatient clinic CS Conv 40–49-y-old men ELISA 41 58.8
Theng et al (2006) [71] 2003–2004 Singapore Outpatient clinic CS Conv >50-y-old men ELISA 37 78.4
Theng et al (2006) [71] 2003–2004 Singapore Outpatient clinic CS Conv <20-y-old female patients ELISA 28 32.1
Theng et al (2006) [71] 2003–2004 Singapore Outpatient clinic CS Conv 20–29-y-old women ELISA 98 49.0
Theng et al (2006) [71] 2003–2004 Singapore Outpatient clinic CS Conv 30–39-y-old women ELISA 40 67.5
Theng et al (2006) [71] 2003–2004 Singapore Outpatient clinic CS Conv >40-y-old women ELISA 32 78.2
Zegans et al (1999) [66] 1999 India Hospital CS Conv Patients with Mooren ulcers ELISA 21 86.0
Clinical Mixed-Age Population (n = 1)
Lee and Lee (2015) [72] NA South Korea Community CSa Conv >11-y-old patients Multiplex immunoassay 2317 73.8
Other Populations (n = 25)
Chu et al (2006) [73] NA Thailand Hospital CS Conv HIV-infected men ELISA 66 53.0
Chu et al (2006) [73] NA Thailand Hospital CS Conv HIV-infected women ELISA 70 73.0
Cowan et al (2003) [56] 1998–2000 Sri Lanka Outpatient clinic CS Conv 15–20-y-old healthy/clinical patients ELISA 622b 74.3
Cowan et al (2003) [56] 1998–2000 Sri Lanka Outpatient clinic CS Conv 20–30-y-old healthy/clinical patients ELISA 622b 79.2
Cowan et al (2003) [56] 1998–2000 Sri Lanka Outpatient clinic CS Conv 30–35-y-old health/clinical patients ELISA 622b 74.6
Cowan et al (2003) [56] 1998–2000 Sri Lanka Outpatient clinic CS Conv 25–40-y-old healthy/clinical patients ELISA 622b 74.5
Cowan et al (2003) [56] 1998–2000 Sri Lanka Outpatient clinic CS Conv 40–45-y-old healthy/clinical patients ELISA 622b 77.1
Cowan et al (2003) [56] 1998–2000 Sri Lanka Outpatient clinic CS Conv >45-y-old healthy/clinical patients ELISA 622b 82.0
Hashido et al (1998) [58] NA Japan Community CS Conv Female sex workers EIA 70 75.7
Hashido et al (1998) [58] NA Japan Community CS Conv <39-y-old MSM EIA 15 53.3
Hashido et al (1998) [58] NA Japan Community CS Conv >40-y-old MSM EIA 19 97.4
Lin et al (2011) [53] NA China Community CS Conv 18–29-y-old HIV-infected patients ELISA 191 94.3
Lin et al (2011) [53] NA China Community CS Conv 30–39-y-old HIV-infected patients ELISA 503 92.6
Lin et al (2011) [53] NA China Community CS Conv 40–49-y-old HIV-infected patients ELISA 290 89.7
Lin et al (2011) [53] NA China Community CS Conv 50–59-y-old HIV-infected patients ELISA 96 85.4
Lin et al (2011) [53] NA China Community CS Conv 60–94-y-old HIV-infected patients ELISA 30 93.3
Limpakarnjanara et al (1999) [74] 1994 Thailand Community CS Conv >16-y-old female sex workers WB 500 91.0
Neal et al (2011) [75] NA China Community CS Conv Sex workers WB 273 91.9
Qutub and Akhter (2003) [76] NA Bangladesh Community CSa Conv Female sex workers WB 463 92.7
Theng et al (2006) [77] 2003–2004 Singapore Outpatient clinic CS Conv 20–29-y-old sex workers ELISA 146 80.1
Theng et al (2006) [77] 2003–2004 Singapore Outpatient clinic CS Conv 30–39-y-old sex workers ELISA 56 67.9
Theng et al (2006) [77] 2003–2004 Singapore Outpatient clinic CS Conv 40–49-y-old sex workers ELISA 60 68.3
Theng et al (2006) [77] 2003–2004 Singapore Outpatient clinic CS Conv >50-y-old sex workers ELISA 38 89.5
Van Griensven et al (2013) [78] 2006–2010 Thailand Community CS Conv >18-y-old MSM ELISA 1740 56.5
Yap et al (2017) [79] NA Malaysia Hospital CS Conv HIV-infected patients ELISA 232 70.7

Abbreviations: CC, case-control; CFT, complement fixation test; Conv, convenience; CS, cross-sectional; EIA, enzyme immunoassay; ELISA, enzyme-linked immunosorbent assay; HIV, human immunodeficiency virus; HSV-1, herpes simplex virus type 1; HTLV-1, human T-lymphotropic virus 1; MSM, men who have sex with men; NA, not available; PHA, passive hemagglutination assay; RS, random sampling; STD, sexually transmitted disease; STI, sexually transmitted infection; WB, Western blot.

aThe actual study design was cohort, but the extracted seroprevalence measure was for the baseline measurement.

bThe study included overall sample size but no sample sizes for individual strata. Each stratum sample size was assumed to be equal to the overall sample size divided by the number of strata in the study.