Fig. 2.

Ex vivo mucosal and systemic homing phenotypes of CD4⁺ T cells following Ty21a oral vaccination. Ex vivo percentages of (A) integrin α4β7⁺, (B) CCR9⁺ and (C) integrin α4β7⁺ CCR9⁺ were evaluated in LPMC and PBMC CD4⁺ T cells isolated from TI biopsies and blood of Ty21a-vaccinated (red symbols; n = 14) and unvaccinated (black symbols; n = 6) volunteers using flow cytometry. Significant differences between TI-LPMC and PBMC in vaccinated and unvaccinated volunteers are denoted as *P < 0.05 and **P < 0.005. P-value for trends was also denoted. Median values for each group are represented as horizontal black bars.