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. 2019 Feb 14;9:2072. doi: 10.1038/s41598-018-37430-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LHX2 overexpression in iPS-HSCs changes the expression profile of the extracellular matrix (ECM), and induces gene expression related to the quiescence phenotype of HSCs. (a) Expression of LHX2 in Veh- or Dox-treated iLHX2-HSCs co-cultured with iPS-HPCs. (b,c) Expression of genes related to HSCs (b, ALCAM, PDGFRα, and WT1) and genes related to the quiescence phenotype of HSCs (c, NGFR, LRAT, Neurotrimin, and PPARγ) in Veh- or Dox-treated iLHX2-HSCs. (d) Expression of genes related to HSC activation (LOX, ACTA2, COL1A1, and Desmin) in Veh- or Dox-treated iLHX2-HSCs co-cultured with iPS-HPCs. (e) Expression profile of laminin and collagen based on microarray analysis. The y-axis represents the ratio of expression relative to Veh-treated iLHX2-HSCs co-cultured with iPS-HPCs. (f) Quantitative RT-PCR analysis of laminin (LAMA2, LAMA4, and LAMA5) and collagen (COL3A1, COL4A5, and COL5A1) in iLHX2-HSCs co-cultured with iPS-HPCs. Results represent the mean ± SD of three separate experiments. The y-axis in (a–d) and (f) represents the ratio of expression relative to Veh-treated iLHX2-HSCs co-cultured with iPS-HPCs. *P < 0.05.