Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 1;9(2):540–553. doi: 10.7150/thno.28374

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Ivyspring International Publisher

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

Association between mutated genes involved in the cereblon pathway and resistance to Pomalidomide. (A) Representation of mutated genes involved in IMiD-mediated CRL4^CRBN activity. Mutated genes are shown in filled ellipses. (B) Seven HMCLs presenting missense mutations of genes involved in the cereblon pathway as well as six HMCLs without mutations (WT) have been treated with Pomalidomide. IC₅₀ of Pomalidomide for each tested HMCL is shown in the table below the heatmap. IC₅₀ of mutated (Mut) and wild type (WT) HMCLs were compared using Wilcoxon test. * : p-value < 0.05. Error bars represent mean standard deviation.