Figure 3.

The roles of PGC-1 in PPCM and DCM. PCG-1α provides cardioprotection against PPCM through three mechanisms: 1) activating anti-oxidative enzyme MnSOD that further inhibits apoptosis of vascular endothelial cells; 2) triggering the provascular VEGF-mediated signaling; and 3) meeting the need of a fuel shift towards FAO driven by PPARs. In the condition of DCM, short- and long-term increases in PGC-1α pathway inhibit and promote insulin resistance, respectively.