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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: Adv Exp Med Biol. 2017;947:71–100. doi: 10.1007/978-3-319-47754-1_4

Fig. 4.5.

Fig. 4.5

Dark field STEM imaging of lung section after repeated dose inhalation and 27 days post treatment. SiO2-MNPs show pores and significant in vivo processing. Almost all of the original spherical morphology has disappeared after 27 days post treatment exposure. SiO2-MNPs show dissolution patterns, void/pore formation (yellow arrows) and significant outward growth of reaction zones (secondary growth shown by blue arrow)