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. 2019 Feb 8;10:66. doi: 10.3389/fphar.2019.00066

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Copyright © 2019 Ercolano, De Cicco, Frecentese, Saccone, Corvino, Giordano, Magli, Fiorino, Severino, Calderone, Citi, Cirino and Ianaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synthetic procedure for the synthesis of naproxen-HBTA (A, 5). H₂S-releasing properties of HBTA evaluated by an amperometric approach. Curve describes the increase of H₂S concentration, with respect to time, following the incubation of HBTA (1 mM) in the assay buffer with () or without () the nucleophile L-cysteine. H₂S was recorded by amperometry; the vertical bars indicate the SEM (B).

Inline graphic — Synthetic procedure for the synthesis of naproxen-HBTA (A, 5). H₂S-releasing properties of HBTA evaluated by an amperometric approach. Curve describes the increase of H₂S concentration, with respect to time, following the incubation of HBTA (1 mM) in the assay buffer with () or without () the nucleophile L-cysteine. H₂S was recorded by amperometry; the vertical bars indicate the SEM (B).