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. 2019 Jan 21;9(3):620–632. doi: 10.7150/thno.30655

Figure 6.

Figure 6

ANTXR2 inhibitor markedly prevented endometriotic lesion formation and reduced lesion size in the mouse model of endometriosis. (A) A cartoon showing the brief procedures to set up the injection animal model of endometriosis. (B) A representative picture showing the lesion from vehicle group and PGG-treated group in the injection mouse model of endometriosis (left panel). Quantitative result (right panel) shows lesion weight of vehicle-treated group (n = 3 mice) and PGG-treated group (25 mg/kg, n = 5 mice). The asterisk (*) indicates P < 0.05. (C) A cartoon showing the brief procedures to set up the therapeutic animal model of endometriosis. (D) A representative picture showing the lesion from vehicle group and PGG-treated group in the therapeutic mouse model of endometriosis (left panel). Quantitative result (right panel) shows lesion weight of vehicle-treated group (n = 3 mice) and PGG-treated group (25 mg/kg, n = 3 mice). Asterisk (*) indicates P < 0.05. (E) Representative pictures showing CD31 and Ki67 staining results in the lesions isolated from mouse animal model of endometriosis treated with vehicle or PGG. Epi: epithelial cells. St: stromal cells; (F) A cartoon showing the current working model in the pathogenesis of endometriosis. Results were presented as means ±SEM. Scale bar: 100 μm.