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The NIR-triggered drug delivery system with mitochondria-responsive drug release and heat shock capabilities. IR780-CSOSA/DOX micelles selectively targeted into tumor mitochondria and realized photothermal conversion upon NIR-laser irradiation, which photothermally triggered drug release and heat shock in mitochondria, resulting in domino effect on ROS burst for cell apoptosis to perform maximized antitumor efficacy.
