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. 2019 Jan 25;9(3):900–919. doi: 10.7150/thno.29515

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CircHMGCS1 affects the IGF signaling pathway via miR-503-5p. (A-B) The proliferation activity of treated HepG2 and HUH6 cell were measured by CCK8 assays (one-way ANOVA, followed by Bonferroni's test) . (C-E) The proliferation activity of treated HepG2 and HUH6 cells were detected by colony formation assays (one-way ANOVA, followed by Bonferroni's test). (F-I) Apoptosis in treated HepG2 and HUH6 cells were measured by FACS assays (one-way ANOVA, followed by Bonferroni's test). (J-K) Western blot assays were performed to measure the indicated protein level in treated HepG2 and HUH6 cells. (L) HepG2/LV-shNC and HepG2/LV-circHMGCS1 cells, treated with 200nM wortmannin for 4h, were lysed for western blot assay to detect the Akt and p-Akt protein levels. The data in A-I indicate mean ± SD and were analyzed by one-way analysis of variance, Bonferroni's test.