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. 2019 Jan 25;9(3):900–919. doi: 10.7150/thno.29515

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CircHMGCS1 promotes HB tumor growth in vivo. (A) CircHMGCS1 knockdown efficiency using shRNAs in HUH6 cells was verified by qRT-PCR (independent-samples t test). (B) Tumors dissected from nude mice inoculated with HUH6/lv-sh_NC (left flank) and HUH6/lv-sh_circHMGCS1 cells (right flank) (n = 7). (C) Tumor volumes (mm³) on the indicated days were graphed to reveal tumor growth curves (two-way ANOVA followed by Bonferroni's test). (D) Average tumor weight of nude mice inoculated with HUH6/lv-sh_NC and HUH6/lv-sh_circHMGCS1 cells (independent-samples t test). *p < 0.05, **p < 0.01, and ***p < 0.001.