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. 2019 Jan 25;9(3):900–919. doi: 10.7150/thno.29515

Figure 9.

Figure 9

IGF2 is highly overexpressed in HB tissues and may be a promising biomarker for the diagnosis and prognosis of HB patients. (A) Grading criteria based on the percentage of cells with different staining intensities at two magnifications (100× and 200×) for defining the IGF2 expression level in tissue sections following IHC. (B) The Pearson's χ2 test of IGF2 in 27 HB and normal tissue pairs. **p = 0.007. (C) Representative pictures of IGF2 staining in tissue sections at three magnifications (100×, 200× and 400×). (D) ROC curve for the use of IGF2 as a diagnostic biomarker (p < 0.0001). (E) Kaplan-Meier analyses of correlations between IGF2 expression levels and OS among 33 HB patients are shown (*p = 0.0194). *p < 0.05, **p < 0.01, and ***p < 0.001.