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. 2019 Jan 24;9(3):676–690. doi: 10.7150/thno.30224

Figure 5.

Figure 5

TBC1D8 expression inhibits OVCA cell PK activity and increases cell glucose uptake and lactate production. (A) OV-3 cells were transfected with the indicated amount of TBC1D8 vector, and the PK activity was evaluated (n=3). (B) OV-3high cells were transfected with two anti-TBC1D8 siRNAs, and the PK activity was determined (n=3). (C) PK activity was determined in OV-3high cells with TBC1D8 expression stably silenced (n=3). (D) PK activity was determined in mouse xenograft tumors composed of OV-3high cells with TBC1D8 expression stably silenced, as described in Figure 3E (n=3). (E, G) OV-3 cells were transfected with the indicated amount of TBC1D8 vector, and glucose uptake (E) and lactate production (G) were determined (n=3). (F, H) OV-3high cells were transfected with two anti-TBC1D8 siRNAs, and glucose uptake (F) and lactate production (H) were determined (n=3).