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TBC1D8 promotes OVCA tumorigenesis and aerobic glycolysis through PKM2. (A-G) TBC1D8 plasmid together with anti-PKM2 siRNA were co-transfected into OVCAR-3 cells, the indicated proteins (A), cell growth (B), migration and invasion (C), colony formation (D), glucose uptake (E), lactate production (F) and PK activity (G) were determined. (H) A proposed model illustrating that TBC1D8 promotes aerobic glycolysis and tumorigenesis by hindering PKM2 tetramerization (n=3).
