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Acid-sensitive DOX release from bDOX. (A-C) HPLC characterization of bDOX hydrolysis after dissolving bDOX in PB buffer solutions with varying pH for different times. Retention time was ~ 23 min for DOX and ~ 25 min for bDOX. (D) Quantification of released DOX from bDOX with varying pH for different times. The values represent mean ± SD (n = 3).
