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Mutant frequencies induced by riddelliine in liver of female transgenic Big Blue rats. The upper panel shows mutant frequencies induced by riddelliine treatment in the cII genes in rat liver as a function of dose. The lower panel compares mutant frequencies with other biological consequences after riddelliine treatments in rat liver hepatocytes (solid bars) and endothelial cells (open bars). Data are from the literature (Chou et al., 2003c; Hirono et al., 1978; Mei et al., 2004a).
