Table 6.

Cox regression analysis of factors associated with limb loss (major amputation).

Variable	Univariate analysis				Multivariate analysis
	B	HR	95% CI	P	B	HR	95% CI	P
Diabetes	.255	.016	.415–5.609	.900	.392	.106	0.415–14.233	.671
Active tobacco use	1.244	.257	.077–44.297	.612	12.244	.001	0.120–14.681	.975
Chronic kidney disease	1.542	.634	.138–11.051	.426	1.542	.908	0.538–4.567	.831
Runoffa	2.412	4.698	1.221–10.501	.039	1.885	7.906	1.411–14.294	.975
PACCS	2.722	.480	.331–21.429	.959	.032	.002	1.531–24.234	.616
TASC AB + CD	.631	1.331	0.542–1.543	.172	0.711	0.915	0.339–12.230	.249
Calcification severityb	1.953	.731	0.024–2.111	.469	4.243	8.314	1.334–5.433	.959
Use of stents (yes/no)	.680	2.323	0.823–4.729	.127	.680	2.323	0.823–4.729	.127
Lesion lengthc	.225	.067	0.146–4.336	.795	.680	.056	0.256–4.759	.987
Arterial segment treatmentd	.464	.912	0.105–3.760	.611	.464	.256	0.105–3.760	.611
Dialysis CKF	.882	.898	0.077–2.442	.343	.676	.288	0.408–4.770	.343
Rutherford 4/5 + 6	.180	.062	0.291–4.927	.803	.722	.106	0.291–4.927	.803
Cardiac failure	.697	.906	0.577–6.986	.273	.456	2.987	0.467–5.325	.273
Cilostazol use	−1.577	1.265	0.017–2.472	.213	−1.567	1.266	0.198–3.456	.213

TASC: Trans-Atlantic Inter-Society Consensus;.B: coefficient; HR: hazard ratio; CI: confidence interval.

^aTwo tibial vessels vs. one tibial vessel + popliteal artery isolated segment.

^bHigh severity score (>2) vs. moderate severity score (<2).

^cLesion length > 6 cm vs. < 6 cm.

^dFemoropopliteal segment angioplasty vs. femoropopliteal + infrapopliteal segment angioplasty.